Alginate-Chitosan Particulate System for Sustained Release of Nimodipine
نویسندگان
چکیده
منابع مشابه
Alginate-Chitosan Particulate System for Sustained Release of Nimodipine
Purpose: The aim of this work was to prepare nimodipine-loaded alginate-chitosan beads for sustained drug release. Methods: Nimodipine-loaded alginate-chitosan beads were prepared by ionic gelation method using various combinations of chitosan and Ca 2+ as cations and alginate as anion. The swelling ability and in vitro drug release characteristics of the beads were studied at pH 1.2 and 6.8. I...
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Background: Inflammatory bone resorption in periodontitis can lead to tooth loss. Systemic administration of bisphosphonates such as risedronate for preventing bone resorption can cause adverse effects. Alginate hydrogel (ALG) and poly (lactic acid-co-glycolic acid) (PLGA) microparticles have been studied as drug delivery systems for sustained release of drugs. Therefore, the release pattern of...
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Recently, efforts have been focused on microparticles prepared with natural polymers such as alginates and chitosans. Sodium alginate in particular has been commercially applied and investigated due to its low cost and minimal processing requirements (Murata et al., 1993; Gombotz & Wee, 1998; Sezer & Akbuga, 1999a and b). The use of sodium alginate for microencapsulation has been extensively st...
متن کاملHydrophilic Natural Polymers for Sustained-controlled Release of Calcium Hydroxide
Calcium Hydroxide (CH) is commonly employed as intracanal medicament in endodontics. In order to maximize its therapeutic effects, it is essential to develop new approaches for preparing the controlled drug release systems which, in turn, facilities the dissociation of CH into calcium and hydroxyl ions. This work studies the sustained-controlled release of calcium ions and the effect of pH chan...
متن کاملHydrophilic Natural Polymers for Sustained-controlled Release of Calcium Hydroxide
Calcium Hydroxide (CH) is commonly employed as intracanal medicament in endodontics. In order to maximize its therapeutic effects, it is essential to develop new approaches for preparing the controlled drug release systems which, in turn, facilities the dissociation of CH into calcium and hydroxyl ions. This work studies the sustained-controlled release of calcium ions and the effect of pH chan...
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ژورنال
عنوان ژورنال: Tropical Journal of Pharmaceutical Research
سال: 2009
ISSN: 1596-9827,1596-5996
DOI: 10.4314/tjpr.v8i5.48087